DNA ligases seal five′-PO4 and 3′-OH polynucleotide finishes via a few nucleotidyl transfer measures involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are vital guardians of genomic integrity, and ligase dysfunction underlies human genetic disease syndromes. Crystal structures of DNA ligases sure to nucleotide and nucleic acid substrates have illuminated https://louisx223cxq7.iyublog.com/profile