Spearman rank correlations involving log Ki for binding in vitro and in vivo log ED50 parameters from the triad test (A–C). Spearman rank correlations involving log EC50 for efficacy in vitro and in vivo log ED50 parameters of the triad exam (E–File). Chromatographic peaks of potential metabolites were found utilizing https://rarechemsonline.org/product/5f-mdmb-2201/