As a way to shift response eqref rxn:four for the still left ligands which preferentially bind to $ce Cu(I) ,$ has to be included to the answer. $ce Cu(I)L_n $ complexes might be stabilized in aqueous alternatives by means of employing ligands with a number of of the following Qualities: https://rnasel-in-146801.dailyhitblog.com/39468606/helping-the-others-realize-the-advantages-of-rnase-l-in-1