In this article, we exhibit that conolidine, a organic analgesic alkaloid used in common Chinese medication, targets ACKR3, thus giving extra evidence of the correlation concerning ACKR3 and discomfort modulation and opening substitute therapeutic avenues for the cure of Persistent soreness. Tabernaemontana divaricata Conolidine can be an indole alkaloid. https://jamesf375jyp9.thecomputerwiki.com/user