There exists a release of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors inside the dorsal horn to reduce afferent ache transmission and produce analgesia. Therefore, medicines like clonidine that goal alpha-2 receptors can impact the transmission of discomfort. You might be able to notify this https://derrickp013wkv1.hamachiwiki.com/user